ea0021oc3.6 | Young Endocrinologists prize session | SFEBES2009
Javid Mahsa
, Walls Gerard
, Lemos Manuel
, Jeyabalan Jeshmi
, Bazan-Peregrino Miriam
, Tyler Damian
, Stuckey Daniel
, Seymour Len
, Thakker Rajesh
Multiple endocrine neoplasia type 1 (MEN1) is characterised by the combined occurrence of pituitary, pancreatic and parathyroid tumours. The MEN1 gene encodes a 610-amino acid tumour suppressor, menin, and MEN1-associated tumours show loss of heterozygosity. This indicates that replacement of the wild-type MEN1 gene may inhibit tumourigenesis. We have previously demonstrated that a recombinant adenoviral vector could be safely injected directly into pituit...